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PTGIS Antibody (PACO04809)

SKU:
PACO04809
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$323

Description

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PTGIS Antibody (PACO04809)

The PTGIS Polyclonal Antibody (PAC004809) is a valuable tool for researchers studying the prostaglandin I2 synthase (PTGIS) protein. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the PTGIS protein, this antibody allows for the detection and analysis of PTGIS expression in a variety of cell types, making it ideal for studies in the fields of immunology and cancer research.

PTGIS is an enzyme involved in the production of prostacyclin, a prostaglandin with anti-inflammatory and anti-thrombotic properties. As such, PTGIS plays a crucial role in regulating vascular tone and platelet aggregation, making it a promising target for therapeutic interventions in diseases such as cardiovascular disorders and cancer. Understanding the function of PTGIS is essential for developing strategies to modulate its activity for therapeutic benefit.

Antibody Name:PTGIS Antibody
Antibody SKU:PACO04809
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from the C-terminal region of human PGI2 synthase.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:PTGIS; CYP8; CYP8A1; Prostacyclin synthase; Prostaglandin I2 synthase
UniProt Protein Function:PTGIS: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2). Belongs to the cytochrome P450 family.
UniProt Protein Details:

Protein type:Lipid Metabolism - arachidonic acid; Membrane protein, integral; Isomerase; EC 5.3.99.4; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 20q13.13

Cellular Component: extracellular space; endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; caveola; nucleus

Molecular Function:protein binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; iron ion binding; heme binding; prostaglandin-I synthase activity; monooxygenase activity

Biological Process: positive regulation of angiogenesis; vitamin metabolic process; NAD metabolic process; inhibition of NF-kappaB transcription factor; nicotinamide metabolic process; negative regulation of nitric oxide biosynthetic process; negative regulation of inflammatory response; xenobiotic metabolic process; cyclooxygenase pathway; icosanoid metabolic process; arachidonic acid metabolic process; prostaglandin biosynthetic process; water-soluble vitamin metabolic process

Disease: Hypertension, Essential

NCBI Summary:This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]
UniProt Code:Q16647
NCBI GenInfo Identifier:2493373
NCBI Gene ID:5740
NCBI Accession:Q16647.1
UniProt Secondary Accession:Q16647,Q3MII8, Q9HAX2, Q9HAX3, Q9HAX4,
UniProt Related Accession:Q16647
Molecular Weight:57,104 Da
NCBI Full Name:Prostacyclin synthase
NCBI Synonym Full Names:prostaglandin I2 (prostacyclin) synthase
NCBI Official Symbol:PTGIS  
NCBI Official Synonym Symbols:CYP8; PGIS; PTGI; CYP8A1  
NCBI Protein Information:prostacyclin synthase; cytochrome P450, family 8, subfamily A, polypeptide 1; prostaglandin I2 synthase
UniProt Protein Name:Prostacyclin synthase
UniProt Synonym Protein Names:Prostaglandin I2 synthase
Protein Family:Prostacyclin receptor
UniProt Gene Name:PTGIS  
UniProt Entry Name:PTGIS_HUMAN

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