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PGE receptor EP4 (PTGER4) Polyclonal Antibody (CAB20295)

SKU:
CAB20295
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
PTGER4
EP4
EP4R
Research Area:
Cell Biology
$431
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Description

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Product Name:PGE receptor EP4 (PTGER4) Polyclonal Antibody
SKU:CAB20295
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-488 of human PGE receptor EP4 (PTGER4) (P35408).
Sequence:MSTP GVNS SASL SPDR LNSP VTIP AVMF IFGV VGNL VAIV VLCK SRKE QKET TFYT LVCG LAVT DLLG TLLV SPVT IATY MKGQ WPGG QPLC EYST FILL FFSL SGLS IICA MSVE RYLA INHA YFYS HYVD KRLA GLTL FAVY ASNV LFCA LPNM GLGS SRLQ YPDT WCFI DWTT NVTA HAAY SYMY AGFS SFLI LATV LCNV LVCG ALLR MHRQ FMRR TSLG TEQH HAAA AASV ASRG HPAA SPAL PRLS DFRR RRSF RRIA GAEI QMVI LLIA TSLV VLIC SIPL VVRV FVNQ LYQP SLER EVSK NPDL QAIR IASV NPIL DPWI YILL RKTV LSKA IEKI KCLF CRIG GSRR ERSG QHCS DSQR TSSA MSGH SRSF ISRE LKEI SSTS QTLL PDLS LPDL SENG LGGR NLLP GVPG MGLA QEDT TSLR TLRI SETS DSSQ GQDS ESVL LVDE AGGS GRAG PAPK GSSL QVTF PSET LNLS EKCI
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:EP4; EP4R; PGE receptor EP4 (PTGER4)
Positive Sample:Rat spleen
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Multi-pass membrane protein.
Calculated MW:53kDa
Observed MW:52kDa

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.

Purification Method:Affinity purification
Gene ID:5734
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of Rat spleen, using PGE receptor EP4 (PTGER4) antibody (CAB20295) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.

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