The PTGDR2 Polyclonal Antibody (PACO2091) is a valuable tool for researchers studying PTGDR2, a G-protein coupled receptor involved in mediating allergic and inflammatory responses. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, providing reliable results in Western blotting and other applications. By targeting the PTGDR2 protein, researchers can gain insights into its function and explore its role in various cellular processes, particularly in the context of immunology and inflammation.
PTGDR2, also known as DP2, is a key player in promoting allergic inflammation and has been implicated in the pathogenesis of asthma and other allergic conditions. By elucidating the mechanisms underlying PTGDR2 activation and signaling, researchers can uncover potential therapeutic targets for managing allergic diseases and developing novel treatments. The PTGDR2 Polyclonal Antibody serves as a valuable tool for investigating the molecular pathways involving PTGDR2 and advancing our understanding of allergic inflammatory responses.
Antibody Name:
PTGDR2 Antibody
Antibody SKU:
PACO02091
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the Internal region of human CD294.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca2+ mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
UniProt Protein Details:
NCBI Summary:
This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011]
