The PTCH2 Polyclonal Antibody (PAC011568) is a valuable tool for researchers studying PTCH2, a critical regulator of the Hedgehog signaling pathway. This antibody, produced in rabbits, is highly specific to human samples and is optimized for Western blot applications, allowing for accurate detection of PTCH2 protein levels.PTCH2 is known for its role in controlling cell growth and differentiation, making it a key player in various physiological processes, including development and tissue repair.
Dysregulation of PTCH2 has been implicated in various diseases, such as cancer and developmental disorders, highlighting its importance as a potential therapeutic target.By using the PTCH2 Polyclonal Antibody, researchers can gain insights into the function of PTCH2 and its impact on cellular processes. This antibody is suitable for use in immunology and cancer research, providing a reliable tool for studying the Hedgehog signaling pathway and its implications in disease pathology.
PTCH2: May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH). Belongs to the patched family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 1p34.1Cellular Component: integral to membraneMolecular Function: hedgehog receptor activity; smoothened bindingBiological Process: skin development; epidermis development; negative regulation of smoothened signaling pathway; signal transduction; hair cycleDisease: Basal Cell Nevus Syndrome; Basal Cell Carcinoma, Susceptibility To, 1; Medulloblastoma
UniProt Protein Details:
NCBI Summary:
This gene encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009]
