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PTAFR Antibody (PACO29248)

SKU:
PACO29248
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • PTAFR Antibody PACO29248
  • PTAFR Antibody PACO29248
  • PTAFR Antibody PACO29248
€339
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Description

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PTAFR Antibody (PACO29248)

The PTAFR Polyclonal Antibody (PACO29248) is a valuable tool for researchers studying the PTAFR protein, which plays a key role in inflammation and immune responses. This antibody, raised in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to the PTAFR protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for studies in immunology, inflammation, and related fields.PTAFR, or Platelet-activating factor receptor, is involved in mediating inflammatory responses in the body and is known to be a crucial player in various diseases, including asthma, cardiovascular diseases, and neurodegenerative disorders.

By studying the function of PTAFR, researchers can gain valuable insights into the underlying mechanisms of these conditions and potentially uncover new therapeutic targets for treatment.Overall, the PTAFR Polyclonal Antibody (PACO29248) is a powerful tool for investigating the role of PTAFR in immune responses and inflammatory processes, paving the way for advancements in the understanding and treatment of a wide range of diseases.

Antibody Name:PTAFR Antibody (PACO29248)
Antibody SKU:PACO29248
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200
Species Reactivity:Human, Mouse
Immunogen:Recombinant Human Platelet-activating factor receptor protein (297-342AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot
All lanes: PTAFR antibody at 4µg/ml + Mouse lung tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 40 kDa
Observed band size: 40 kDa
.
Product ImageImmunofluorescent analysis of A431 cells using PACO29248 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Product ImageImmunohistochemistry of paraffin-embedded human kidney tissue using PACO29248 at dilution of 1:100.
Background:Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.
Synonyms:Platelet-activating factor receptor (PAF-R) (PAFr), PTAFR, PAFR
UniProt Protein Function:PTAFR: Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCRChromosomal Location of Human Ortholog: 1p35-p34.3Cellular Component: nucleoplasm; membrane; intracellular membrane-bound organelle; integral to plasma membrane; integral to membrane; plasma membraneMolecular Function: G-protein coupled receptor activity; platelet activating factor receptor activity; purinergic nucleotide receptor activity, G-protein coupled; lipopolysaccharide binding; phospholipid binding; lipopolysaccharide receptor activityBiological Process: G-protein coupled receptor protein signaling pathway; phosphoinositide-mediated signaling; inositol trisphosphate biosynthetic process; cytokine and chemokine mediated signaling pathway; lipopolysaccharide-mediated signaling pathway; cytokine production; immune response; inflammatory response; chemotaxis
UniProt Protein Details:
NCBI Summary:This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
UniProt Code:P25105
NCBI GenInfo Identifier:257900493
NCBI Gene ID:5724
NCBI Accession:NP_001158195.1
UniProt Secondary Accession:P25105,A3KMC8, A8K2H5
UniProt Related Accession:P25105
Molecular Weight:39,203 Da
NCBI Full Name:platelet-activating factor receptor
NCBI Synonym Full Names:platelet-activating factor receptor
NCBI Official Symbol:PTAFR  
NCBI Official Synonym Symbols:PAFR  
NCBI Protein Information:platelet-activating factor receptor; PAF-R
UniProt Protein Name:Platelet-activating factor receptor
UniProt Synonym Protein Names:
Protein Family:
UniProt Gene Name:PTAFR  
UniProt Entry Name:PTAFR_HUMAN
Antibodies
PTAFR Antibody (PACO04803)
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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