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PTAFR Antibody (PACO18800)

SKU:
PACO18800
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339

Description

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PTAFR Antibody (PACO18800)

The PTAFR Polyclonal Antibody (PACO18800) is a valuable tool for researchers studying the Platelet-Activating Factor Receptor (PTAFR), a G-protein coupled receptor involved in various cellular responses such as inflammation, allergy, and cancer progression. This antibody, raised in rabbits, specifically targets the PTAFR protein and is highly reactive with human samples.Validated for use in Western blot applications, the PTAFR Polyclonal Antibody enables researchers to detect and analyze PTAFR expression in different cell types, making it ideal for studies in immunology, oncology, and inflammation research.

By understanding the role of PTAFR in these processes, researchers can develop targeted therapies for conditions related to inflammatory responses and cancer progression.The PTAFR Polyclonal Antibody is a critical tool for uncovering the mechanisms behind PTAFR signaling and its impact on disease development, paving the way for potential therapeutic interventions targeting this receptor.

Antibody Name:PTAFR Antibody (PACO18800)
Antibody SKU:PACO18800
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:Human
Immunogen:Synthetic peptide of human PTAFR
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO18800(PTAFR Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.
Synonyms:Platelet-activating factor receptor
UniProt Protein Function:PTAFR: Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCRChromosomal Location of Human Ortholog: 1p35-p34.3Cellular Component: nucleoplasm; membrane; intracellular membrane-bound organelle; integral to plasma membrane; integral to membrane; plasma membraneMolecular Function: G-protein coupled receptor activity; platelet activating factor receptor activity; purinergic nucleotide receptor activity, G-protein coupled; lipopolysaccharide binding; phospholipid binding; lipopolysaccharide receptor activityBiological Process: G-protein coupled receptor protein signaling pathway; phosphoinositide-mediated signaling; inositol trisphosphate biosynthetic process; cytokine and chemokine mediated signaling pathway; lipopolysaccharide-mediated signaling pathway; cytokine production; immune response; inflammatory response; chemotaxis
UniProt Protein Details:
NCBI Summary:This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
UniProt Code:P25105
NCBI GenInfo Identifier:257900493
NCBI Gene ID:5724
NCBI Accession:NP_001158195.1
UniProt Secondary Accession:P25105,A3KMC8, A8K2H5
UniProt Related Accession:P25105
Molecular Weight:39,203 Da
NCBI Full Name:platelet-activating factor receptor
NCBI Synonym Full Names:platelet-activating factor receptor
NCBI Official Symbol:PTAFR  
NCBI Official Synonym Symbols:PAFR  
NCBI Protein Information:platelet-activating factor receptor; PAF-R
UniProt Protein Name:Platelet-activating factor receptor
UniProt Synonym Protein Names:
Protein Family:
UniProt Gene Name:PTAFR  
UniProt Entry Name:PTAFR_HUMAN
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