The PSTPIP1 Polyclonal Antibody (CAB7760) is a valuable tool for researchers studying PSTPIP1, a protein involved in inflammatory responses and immune regulation. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By binding to the PSTPIP1 protein, this antibody allows for accurate detection and analysis in various cell types, making it essential for studies in immunology and inflammatory conditions.PSTPIP1, also known as proline-serine-threonine phosphatase-interacting protein 1, plays a crucial role in regulating the inflammatory response by modulating the activation of immune cells.
Its involvement in immune regulation makes it a promising target for research in diseases such as autoimmune disorders, inflammatory conditions, and even cancer. Understanding the function of PSTPIP1 is key to developing targeted therapies that can modulate immune responses in these disease contexts.Overall, the PSTPIP1 Polyclonal Antibody (CAB7760) offers researchers a reliable tool to study the role of PSTPIP1 in immune regulation and inflammatory processes, opening up new avenues for therapeutic development and deeper insights into immune-related diseases.
Product Name:
PSTPIP1 Rabbit Polyclonal Antibody
SKU:
CAB7760
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 157-416 of human PSTPIP1 (NP_003969.2).
This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response.
Purification Method:
Affinity purification
Gene ID:
9051
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PSTPIP1 Rabbit pAb (CAB7760) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 40s.
