PSTPIP1 Rabbit Polyclonal Antibody (CAB7760)
- SKU:
- CAB7760
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | PSTPIP1 Rabbit Polyclonal Antibody |
SKU: | CAB7760 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 157-416 of human PSTPIP1 (NP_003969.2). |
Sequence: | AFER ISAN GHQK QVEK SQNK ARQC KDSA TEAE RVYR QSIA QLEK VRAE WEQE HRTT CEAF QLQE FDRL TILR NALW VHSN QLSM QCVK DDEL YEEV RLTL EGCS IDAD IDSF IQAK STGT EPPA PVPY QNYY DREV TPLT SSPG IQPS CGMI KRFS GLLH GSPK TTSL AASA ASTE TLTP TPER NEGV YTAI AVQE IQGN PASP AQEY RALY DYTA QNPD ELDL SAGD ILEV ILEG EDGW WTVE RNGQ RGFV PGSY LEKL |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | H-PIP; PAPAS; CD2BP1; PSTPIP; CD2BP1L; CD2BP1S; PSTPIP1 |
Positive Sample: | THP-1,mouse spleen,mouse thymus,mouse brain,rat brain,Mouse spleen,Mouse thymus,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell projection, Cleavage furrow, Cytoplasm, cytoskeleton, lamellipodium, perinuclear region, uropodium. |
Calculated MW: | 48kDa |
Observed MW: | 48kDa |
This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response.
Purification Method: | Affinity purification |
Gene ID: | 9051 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |