The PSPN Polyclonal Antibody (PAC018431) is a valuable tool for researchers studying PSPN, a protein involved in various biological processes, including immune regulation and cell signaling. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.PSPN, also known as persephin, plays a crucial role in the development and function of the nervous system, making it a key target for studies in neuroscience and neurology. By detecting PSPN at the protein level, researchers can gain valuable insights into its functions and mechanisms of action in different cell types and tissues.
Furthermore, PSPN has been implicated in various disease states, including neurodegenerative disorders and cancer. By studying the expression and activity of PSPN using this antibody, researchers can potentially uncover new therapeutic targets and strategies for treating these conditions. Stay at the forefront of PSPN research with the PAC018431 Polyclonal Antibody.
Antibody Name:
PSPN Antibody (PACO18431)
Antibody SKU:
PACO18431
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human PSPN
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18431(PSPN Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18431(PSPN Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene is a neurotrophic factor, belonging to the GDNF family. Neurotrophic factors are important for the proper development and maintenance of the nervous system. These factors promote neuronal survival and can prevent the neuronal degeneration associated with injury, toxin exposure, or neurodegenerative disease. The encoded protein has amino acid, similarity to its other family members, glial cell line-derived neurotrophic factor and neurturin. This gene product promotes the survival of ventral midbrain dopaminergic neurons in culture and prevents their degeneration after 6-hydroxydopamine treatment in vivo.
Synonyms:
persephin
UniProt Protein Function:
PSPN: Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons. Belongs to the TGF-beta family. GDNF subfamily.
Biological Process: nervous system development; axon guidance; central nervous system development; ureteric bud branching
NCBI Summary:
The protein encoded by this gene is a neurotrophic factor, belonging to the GDNF family. Neurotrophic factors are important for the proper development and maintenance of the nervous system. These factors promote neuronal survival and can prevent the neuronal degeneration associated with injury, toxin exposure, or neurodegenerative disease. The encoded protein has amino acid similarity to its other family members, glial cell line-derived neurotrophic factor and neurturin. This gene product promotes the survival of ventral midbrain dopaminergic neurons in culture and prevents their degeneration after 6-hydroxydopamine treatment in vivo. [provided by RefSeq, Jul 2008]
