The PSPN Antibody (PAC018430) is a high-quality polyclonal antibody developed for research involving PSPN, a protein that plays a role in immune regulation. This antibody, produced in rabbits, shows a strong reactivity with human samples and is specifically validated for use in Western blot applications. By binding to the PSPN protein, this antibody enables precise detection and analysis in various cell types, making it an ideal tool for studies in immunology and cancer research.
PSPN, also known as a key player in immune modulation, is involved in regulating immune responses and inflammation. Its importance in immune system balance makes it a valuable target for research on diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the function of PSPN is crucial for developing therapeutic interventions that can manipulate immune responses in these disease contexts.
Antibody Name:
PSPN Antibody (PACO18430)
Antibody SKU:
PACO18430
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human PSPN
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO18430(PSPN Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18430(PSPN Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene is a neurotrophic factor, belonging to the GDNF family. Neurotrophic factors are important for the proper development and maintenance of the nervous system. These factors promote neuronal survival and can prevent the neuronal degeneration associated with injury, toxin exposure, or neurodegenerative disease. The encoded protein has amino acid, similarity to its other family members, glial cell line-derived neurotrophic factor and neurturin. This gene product promotes the survival of ventral midbrain dopaminergic neurons in culture and prevents their degeneration after 6-hydroxydopamine treatment in vivo.
Synonyms:
persephin
UniProt Protein Function:
PSPN: Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons. Belongs to the TGF-beta family. GDNF subfamily.
Biological Process: nervous system development; axon guidance; central nervous system development; ureteric bud branching
NCBI Summary:
The protein encoded by this gene is a neurotrophic factor, belonging to the GDNF family. Neurotrophic factors are important for the proper development and maintenance of the nervous system. These factors promote neuronal survival and can prevent the neuronal degeneration associated with injury, toxin exposure, or neurodegenerative disease. The encoded protein has amino acid similarity to its other family members, glial cell line-derived neurotrophic factor and neurturin. This gene product promotes the survival of ventral midbrain dopaminergic neurons in culture and prevents their degeneration after 6-hydroxydopamine treatment in vivo. [provided by RefSeq, Jul 2008]
