The PSME2 Polyclonal Antibody (CAB13631) is a valuable tool for researchers studying the PSME2 protein, which is known to play a crucial role in the regulation of the immune system and in the degradation of cellular proteins. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.PSME2, also known as the proteasome activator complex subunit 2, is involved in the activation of the 20S proteasome, which is responsible for degrading unwanted or damaged proteins in the cell. Dysregulation of PSME2 has been linked to various diseases, including cancer and autoimmune disorders.
Therefore, understanding the function and regulation of PSME2 is essential for developing targeted therapies and interventions.By utilizing the PSME2 Polyclonal Antibody, researchers can accurately detect and analyze the PSME2 protein in a variety of cell types, providing valuable insights into its role in cellular processes and disease pathology. This antibody is an essential tool for studies focused on immunology, cancer research, and cellular protein degradation pathways.
Product Name:
PSME2 Rabbit Polyclonal Antibody
SKU:
CAB13631
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-239 of human PSME2 (NP_002809.2).
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13.
Purification Method:
Affinity purification
Gene ID:
5721
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts from wild type(WT) and PSME2 knockout (KO) 293T(KO) cells, using PSME2 antibody (CAB13631) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
