PSME1 Rabbit Monoclonal Antibody (CAB5070)
- SKU:
- CAB5070
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- HEL-S-129m
- IFI5111
- PA28A
- PA28alpha
- REGalpha
- Research Area:
- Cell Biology
Description
Product Name: | PSME1 Rabbit Monoclonal Antibody |
SKU: | CAB5070 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-115 of human PSME1(NP_006254.1). |
Sequence: | MAML RVQP EAQA KVDV FRED LCTK TENL LGSY FPKK ISEL DAFL KEPA LNEA NLSN LKAP LDIP VPDP VKEK EKEE RKKQ QEKE DKDE KKKG EDED KGPP CGPV NCNE KIVV LLQ |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | PA28A; IFI5111; REGalpha; PA28alpha; HEL-S-129m; PSME1 |
Positive Sample: | MCF7,Mouse liver,Mouse spleen,Rat lung,Rat spleen |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Cytosol, Extracellular exosome, Nucleoplasm |
Calculated MW: | 29kDa |
Observed MW: | 28kDa |
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 5720 |
Clone Number: | ARC1254 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |