The PSMD9 Polyclonal Antibody (CAB5357) is a valuable tool for researchers studying the PSMD9 protein, a subunit of the 26S proteasome complex involved in protein degradation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.PSMD9 plays a crucial role in maintaining cellular homeostasis by regulating the turnover of proteins involved in various cellular processes. Dysregulation of the proteasome complex, including PSMD9, has been linked to diseases such as cancer, neurodegenerative disorders, and autoimmune conditions.
By targeting PSMD9, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.This PSMD9 Polyclonal Antibody enables the detection and analysis of PSMD9 in different cell types, making it an ideal tool for investigations in molecular biology, cell biology, and pharmacology. By understanding the function and regulation of PSMD9, researchers can advance our knowledge of protein degradation pathways and their implications in health and disease.
Product Name:
PSMD9 Rabbit Polyclonal Antibody
SKU:
CAB5357
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-223 of human PSMD9 (NP_002804.2).
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5715
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PSMD9 antibody (CAB5357) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).
