The PSMD7 Polyclonal Antibody (CAB5356) is specifically designed for research involving PSMD7, a subunit of the 26S proteasome complex that plays a crucial role in protein degradation within cells. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the PSMD7 protein, this antibody enables the detection and analysis of PSMD7 in various cell types, making it an ideal tool for research in the fields of cell biology and molecular biology.PSMD7 is essential for the proper functioning of the proteasome complex, which is responsible for degrading damaged or unwanted proteins in the cell.
Dysregulation of PSMD7 has been implicated in various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. Therefore, studying the role of PSMD7 and its interactions within the proteasome complex is crucial for understanding the molecular mechanisms underlying these diseases and developing potential therapeutic interventions.Overall, the PSMD7 Polyclonal Antibody (CAB5356) provides researchers with a valuable tool for investigating the function of PSMD7 and its implications in various disease states. Its high reactivity and specificity make it a reliable option for studying protein degradation pathways and their role in cellular homeostasis.
Product Name:
PSMD7 Rabbit Polyclonal Antibody
SKU:
CAB5356
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-324 of human PSMD7 (NP_002802.2).
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 17.
Purification Method:
Affinity purification
Gene ID:
5713
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PSMD7 Rabbit pAb (CAB5356) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
