PSMD4 Rabbit Monoclonal Antibody (CAB3663)
- SKU:
- CAB3663
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | PSMD4 Rabbit Monoclonal Antibody |
SKU: | CAB3663 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human PSMD4 (P55036). |
Sequence: | TTGT EDSD DALL KMTI SQQE FGRT GLPD LSSM TEEE QIAY AMQM SLQG AEFG QAES ADID ASSA MDTS EPAK EEDD YDVM QDPE FLQS VLEN LPGV DPNN E |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | AF; ASF; S5A; AF-1; MCB1; Rpn10; pUB-R5; PSMD4 |
Positive Sample: | A549,U-251MG,Mouse testis,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytosol, Nucleoplasm, Nucleus |
Calculated MW: | 41kDa |
Observed MW: | 55kDa |
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21.
Purification Method: | Affinity purification |
Gene ID: | 5710 |
Clone Number: | ARC0818 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |