PSMD2 Rabbit Polyclonal Antibody (CAB1999)
- SKU:
- CAB1999
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | PSMD2 Rabbit Polyclonal Antibody |
SKU: | CAB1999 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PSMD2 (NP_002799.3). |
Sequence: | MEEG GRDK APVQ PQQS PAAA PGGT DEKP SGKE RRDA GDKD KEQE LSEE DKQL QDEL EMLV ERLG EKDT SLYR PALE ELRR QIRS STTS MTSV PKPL KFLR PHYG KLKE IYEN MAPG ENKR FAAD IISV LAMT MSGE RECL KYRL VGSQ EELA SWGH EYVR HLAG EVAK EWQE LDDA EKVQ REPL LTLV KEIV PYNM AHNA EHEA CDLL MEIE QVDM LEKD IDEN AYAK VCLY LTSC VNYV PEPE NSAL LRCA LGVF RKFS |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | S2; P97; RPN1; TRAP2; PSMD2 |
Positive Sample: | SW480,OVCAR3,M21,U-937,SH-SY5Y,Mouse testis,Mouse heart,Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol, extracellular exosome, extracellular region, nucleoplasm, nucleus, proteasome storage granule |
Calculated MW: | 100kDa |
Observed MW: | 108kDa |
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene.
Purification Method: | Affinity purification |
Gene ID: | 5708 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |