The PSMD13 Polyclonal Antibody (CAB6956) is a valuable tool for research involving the PSMD13 protein, a subunit of the 26S proteasome complex essential for protein degradation. This antibody, generated in rabbits, is highly specific to human samples and has been rigorously validated for use in Western blotting applications.PSMD13 is involved in the regulation of protein turnover, playing a crucial role in cellular processes such as cell cycle control, DNA repair, and antigen processing. Dysregulation of the proteasome complex, including PSMD13, has been linked to various diseases, including cancer and neurodegenerative disorders.
The PSMD13 Polyclonal Antibody enables the detection and analysis of PSMD13 in different cell types, making it an ideal tool for research in molecular biology, cancer biology, and drug development.By understanding the function and regulation of PSMD13, researchers can gain insights into cellular processes and diseases where protein degradation is dysregulated. This antibody serves as a key resource for studying the role of PSMD13 in cellular homeostasis and disease pathology, paving the way for potential therapeutic interventions targeting the proteasome complex.
Product Name:
PSMD13 Rabbit Polyclonal Antibody
SKU:
CAB6956
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human PSMD13 (NP_002808.3).
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
5719
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PSMD13 Rabbit pAb (CAB6956) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
