PSMD12 Rabbit Polyclonal Antibody (CAB6708)
- SKU:
- CAB6708
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | PSMD12 Rabbit Polyclonal Antibody |
SKU: | CAB6708 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 197-456 of human PSMD12 (NP_002807.1). |
Sequence: | KDYI RTQI ISKK INTK FFQE ENTE KLKL KYYN LMIQ LDQH EGSY LSIC KHYR AIYD TPCI QAES EKWQ QALK SVVL YVIL APFD NEQS DLVH RISG DKKL EEIP KYKD LLKL FTTM ELMR WSTL VEDY GMEL RKGS LESP ATDV FGST EEGE KRWK DLKN RVVE HNIR IMAK YYTR ITMK RMAQ LLDL SVDE SEAF LSNL VVNK TIFA KVDR LAGI INFQ RPKD PNNL LNDW SQKL NSLM SLVN KTTH LIAK EEMI HNLQ |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | p55; Rpn5; STISS; PSMD12 |
Positive Sample: | MCF7,BT-474,HT-29,Mouse heart,Rat heart,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytosol, extracellular exosome, extracellular region, nucleoplasm |
Calculated MW: | 53kDa |
Observed MW: | 53kDa |
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 5718 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |