The PSMD11 Polyclonal Antibody (CAB15306) is a valuable tool for researchers studying the PSMD11 protein, a crucial component of the 26S proteasome complex involved in protein degradation. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the PSMD11 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it ideal for investigations in the fields of molecular biology and oncology.
PSMD11 plays a critical role in the regulation of protein turnover and degradation, making it a key player in various cellular processes such as cell cycle control, DNA repair, and immune response. Dysregulation of the proteasome system, including PSMD11, has been implicated in the development of diseases like cancer, neurodegenerative disorders, and autoimmune conditions. Understanding the function and regulation of PSMD11 is essential for advancing research and developing targeted therapies in these disease areas.
Product Name:
PSMD11 Rabbit Polyclonal Antibody
SKU:
CAB15306
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 253-422 of human PSMD11 (NP_002806.2).
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
5717
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PSMD11 antibody (CAB15306) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
