The PSMD1 Polyclonal Antibody (CAB16420) is a powerful tool for research involving the PSMD1 protein, a key component of the 26S proteasome complex. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the PSMD1 protein, this antibody allows for the visualization and analysis of protein degradation pathways in various cell types.The PSMD1 protein is essential for protein turnover and regulation within cells, making it a central player in maintaining cellular homeostasis. Dysregulation of the proteasome complex, of which PSMD1 is a crucial component, has been implicated in various diseases including cancer, neurodegenerative disorders, and autoimmune conditions.
By studying the function and activity of PSMD1, researchers can gain valuable insights into these disease mechanisms and potentially uncover new therapeutic targets.Overall, the PSMD1 Polyclonal Antibody is a valuable tool for researchers working in the fields of cell biology, proteasome function, and disease pathology. Its high specificity and sensitivity make it an ideal choice for studying the intricate regulatory pathways involving the PSMD1 protein.
Product Name:
PSMD1 Rabbit Polyclonal Antibody
SKU:
CAB16420
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 794-953 of human PSMD1 (NP_002798.2).
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes the largest non-ATPase subunit of the 19S regulator lid, which is responsible for substrate recognition and binding. There is evidence that this proteasome and its subunits interact with viral proteins, including those of coronaviruses. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5707
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PSMD1 Rabbit pAb (CAB16420) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
