PSMD1 Rabbit Polyclonal Antibody (CAB16420)
- SKU:
- CAB16420
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | PSMD1 Rabbit Polyclonal Antibody |
SKU: | CAB16420 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 794-953 of human PSMD1 (NP_002798.2). |
Sequence: | DLKM PKVQ YKSN CKPS TFAY PAPL EVPK EKEK EKVS TAVL SITA KAKK KEKE KEKK EEEK MEVD EAEK KEEK EKKK EPEP NFQL LDNP ARVM PAQL KVLT MPET CRYQ PFKP LSIG GIII LKDT SEDI EELV EPVA AHGP KIEE EEQE PEPP EPFE YIDD |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | S1; P112; Rpn2; PSMD1 |
Positive Sample: | 293T,HeLa,Jurkat |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol, extracellular region, nucleoplasm, nucleus, proteasome storage granule |
Calculated MW: | 106kDa |
Observed MW: | 106kDa |
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes the largest non-ATPase subunit of the 19S regulator lid, which is responsible for substrate recognition and binding. There is evidence that this proteasome and its subunits interact with viral proteins, including those of coronaviruses. Alternatively spliced transcript variants have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 5707 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |