The PSMC6 Polyclonal Antibody (CAB5377) is a valuable tool for researchers studying the PSMC6 protein, a subunit of the 26S proteasome complex involved in protein degradation. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the PSMC6 protein, this antibody allows for the detection and analysis of PSMC6 expression in various cell types, making it ideal for investigations in cell biology and cancer research.PSMC6 is a crucial component of the proteasome complex, which plays a vital role in maintaining cellular protein homeostasis by degrading misfolded or damaged proteins. Dysregulation of the proteasome complex has been implicated in various diseases, including cancer, neurodegenerative disorders, and autoimmune conditions.
Studying the function of PSMC6 can provide insights into the mechanisms of these diseases and potentially lead to the development of targeted therapies aimed at modulating protein degradation pathways. Overall, the PSMC6 Polyclonal Antibody (CAB5377) represents a valuable tool for researchers investigating the role of the proteasome complex in cellular processes and disease pathways. Its specificity and reliability make it a key asset for advancing our understanding of protein degradation mechanisms and identifying new therapeutic targets.
Product Name:
PSMC6 Rabbit Polyclonal Antibody
SKU:
CAB5377
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-150 of human PSMC6 (NP_002797.3).
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12.
Purification Method:
Affinity purification
Gene ID:
5706
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PSMC6 Rabbit pAb (CAB5377) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
