PSMC5 Rabbit Polyclonal Antibody (CAB13537)
- SKU:
- CAB13537
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | PSMC5 Rabbit Polyclonal Antibody |
SKU: | CAB13537 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 127-406 of human PSMC5 (NP_002796.4). |
Sequence: | LPNK VDPL VSLM MVEK VPDS TYEM IGGL DKQI KEIK EVIE LPVK HPEL FEAL GIAQ PKGV LLYG PPGT GKTL LARA VAHH TDCT FIRV SGSE LVQK FIGE GARM VREL FVMA REHA PSII FMDE IDSI GSSR LEGG SGGD SEVQ RTML ELLN QLDG FEAT KNIK VIMA TNRI DILD SALL RPGR IDRK IEFP PPNE EARL DILK IHSR KMNL TRGI NLRK IAEL MPGA SGAE VKGV CTEA GMYA LRER RVHV TQED FEMA VAKV MQKD SEKN MSIK KLWK |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | S8; p45; RPT6; SUG1; SUG-1; TBP10; TRIP1; p45/SUG; PSMC5 |
Positive Sample: | HepG2,MCF7,HeLa,293T,NIH/3T3 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 46kDa |
Observed MW: | 45kDa |
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 5705 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |