The PSMC3IP Polyclonal Antibody (PAC011542) is a vital tool for researchers studying the PSMC3IP protein, a key component of the 26S proteasome complex involved in protein degradation. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blotting applications. By targeting the PSMC3IP protein, this antibody allows for precise detection and analysis in a variety of cell types, making it perfect for investigations in biochemistry and molecular biology.PSMC3IP, also known as proteasome 26S subunit, is essential for the proper function of the proteasome complex, which plays a crucial role in regulating cellular processes by degrading proteins.
Dysfunction in the proteasome system has been linked to various diseases, including cancer, neurodegenerative disorders, and autoimmune conditions. Research on PSMC3IP is critical for understanding the mechanisms underlying these diseases and developing potential therapeutic interventions that target the proteasome complex.
PSMC3IP: Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1- promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors. Defects in PSMC3IP are the cause of ovarian dysgenesis type 3 (ODG3). A disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads. Belongs to the HOP2 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Nuclear receptor co-regulatorChromosomal Location of Human Ortholog: 17q21.2Cellular Component: nucleusMolecular Function: DNA binding; ligand-dependent nuclear receptor transcription coactivator activityBiological Process: meiotic cell cycle; DNA recombinationDisease: Ovarian Dysgenesis 3
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein that functions in meiotic recombination. It is a subunit of the PSMC3IP/MND1 complex, which interacts with PSMC3/TBP1 to stimulate DMC1- and RAD51-mediated strand exchange during meiosis. The protein encoded by this gene can also co-activate ligand-driven transcription mediated by estrogen, androgen, glucocorticoid, progesterone, and thyroid nuclear receptors. Mutations in this gene cause XX female gonadal dysgenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2011]
