The PSMC3 Polyclonal Antibody (CAB1986) is a valuable tool for researchers studying the PSMC3 protein, a subunit of the 26S proteasome complex that plays a crucial role in protein degradation. This antibody, generated in rabbits, exhibits high specificity for PSMC3 in human samples and is suitable for use in Western blotting applications.PSMC3 is essential for the proper functioning of the proteasome, a major component of the cellular protein degradation machinery. Dysregulation of PSMC3 has been linked to various diseases, including cancer and neurodegenerative disorders. By targeting PSMC3, researchers can gain insights into the mechanisms underlying these diseases and potentially identify novel therapeutic targets.
This antibody allows for the detection and analysis of PSMC3 in different cell types, providing researchers with a valuable tool for dissecting the role of this protein in various physiological and pathological processes. Its versatility and specificity make it an ideal choice for studies in areas such as cell biology, cancer research, and drug discovery. Unlock the potential of PSMC3 research with the CAB1986 Polyclonal Antibody.
Product Name:
PSMC3 Rabbit Polyclonal Antibody
SKU:
CAB1986
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human PSMC3 (NP_002799.3).
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.
Purification Method:
Affinity purification
Gene ID:
5702
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PSMC3 Rabbit pAb (CAB1986) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
