PSMC3 Rabbit Polyclonal Antibody (CAB13345)
- SKU:
- CAB13345
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | PSMC3 Rabbit Polyclonal Antibody |
SKU: | CAB13345 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human PSMC3 (NP_002799.3). |
Sequence: | MEEG GRDK APVQ PQQS PAAA PGGT DEKP SGKE RRDA GDKD KEQE LSEE DKQL QDEL EMLV ERLG EKDT SLYR PALE ELRR QIRS STTS MTSV PKPL KFLR PHYG KLKE IYEN MAPG ENKR FAAD IISV LAMT MSGE RECL KYRL VGSQ EELA SWGH EYVR HLAG EVAK EWQE LDDA EKVQ |
Tested Applications: | WB IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | RPT5; TBP1; DCIDP; PSMC3 |
Positive Sample: | MCF7,Jurkat |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus, P-body. |
Calculated MW: | 49kDa |
Observed MW: | 50kDa |
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.
Purification Method: | Affinity purification |
Gene ID: | 5702 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |