PSMC1 Rabbit Polyclonal Antibody (CAB15712)
- SKU:
- CAB15712
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | PSMC1 Rabbit Polyclonal Antibody |
SKU: | CAB15712 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 77-440 of human PSMC1 (NP_002793.2). |
Sequence: | EFIR NQEQ MKPL EEKQ EEER SKVD DLRG TPMS VGTL EEII DDNH AIVS TSVG SEHY VSIL SFVD KDLL EPGC SVLL NHKV HAVI GVLM DDTD PLVT VMKV EKAP QETY ADIG GLDN QIQE IKES VELP LTHP EYYE EMGI KPPK GVIL YGPP GTGK TLLA KAVA NQTS ATFL RVVG SELI QKYL GDGP KLVR ELFR VAEE HAPS IVFI DEID AIGT KRYD SNSG GERE IQRT MLEL LNQL DGFD SRGD VKVI MATN RIET LDPA LIRP GRID RKIE FPLP DEKT KKRI FQIH TSRM TLAD DVTL DDLI MAKD DLSG ADIK AICT EAGL MALR ERRM KVTN EDFK KSKE NVLY KKQE GTPE GLYL |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:100 - 1:200 |
Synonyms: | S4; p56; RPT2; P26S4; NEDGTH; PSMC1 |
Positive Sample: | A-549,DU145,Jurkat,HeLa,Mouse brain,Mouse heart,Mouse kidnay,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Lipid-anchor, Membrane, Nucleus. |
Calculated MW: | 49kDa |
Observed MW: | 58kDa |
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder.
Purification Method: | Affinity purification |
Gene ID: | 5700 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |