The PSMB9 Polyclonal Antibody (CAB1771) is a valuable tool for researchers studying the immune system and cellular processes. This antibody, generated in rabbits, specifically targets the PSMB9 protein, also known as the immunoproteasome subunit beta-1i. It is highly reactive with human samples and has been validated for use in Western blot applications.The PSMB9 protein is a critical component of the immunoproteasome, which plays a key role in antigen processing and presentation. By targeting PSMB9, researchers can investigate its functions in various cell types and its involvement in immune responses.
This antibody is ideal for studies in immunology, cancer research, and autoimmune disorders, providing valuable insights into the mechanisms underlying these conditions.Understanding the role of PSMB9 in the immune system can lead to the development of novel therapies targeting the proteasome pathway for the treatment of diseases such as cancer, autoimmune disorders, and inflammatory conditions. The PSMB9 Polyclonal Antibody is a reliable tool for researchers seeking to unravel the complexities of the immune system and discover new therapeutic strategies.
Product Name:
PSMB9/LMP2 Rabbit Polyclonal Antibody
SKU:
CAB1771
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-219 of human PSMB9/LMP2 (NP_002791.1).
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit.
Purification Method:
Affinity purification
Gene ID:
5698
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PSMB9/LMP2 Rabbit pAb (CAB1771) at 1:1000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime: 90s.
