The PSMB6 Polyclonal Antibody (CAB4053) is a valuable tool for researchers studying the proteasome subunit PSMB6. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the PSMB6 protein, this antibody allows for the detection and analysis of PSMB6 in various cell types, making it an essential tool for investigations in immunology and cancer research.PSMB6 is a key component of the proteasome complex, responsible for degrading damaged or misfolded proteins to maintain cellular homeostasis. Dysregulation of PSMB6 has been implicated in various diseases, including cancer and neurodegenerative disorders.
Understanding the role of PSMB6 in cellular processes is essential for developing targeted therapies that can modulate protein degradation pathways and potentially treat these conditions effectively.In conclusion, the PSMB6 Polyclonal Antibody (CAB4053) is a valuable resource for researchers looking to delve deeper into the functions of the PSMB6 proteasome subunit and its implications in disease pathology. Its high reactivity and specificity make it an ideal choice for studies aiming to uncover new insights into protein degradation mechanisms and potential therapeutic targets.
Product Name:
PSMB6 Rabbit Polyclonal Antibody
SKU:
CAB4053
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 35-239 of human PSMB6 (NP_002789.1).
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
5694
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using PSMB6 Rabbit pAb (CAB4053) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
