The PSMB3 Polyclonal Antibody (CAB9947) is a valuable tool for researchers interested in studying the PSMB3 protein, a subunit of the proteasome complex involved in protein degradation. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the PSMB3 protein, this antibody enables the detection and analysis of PSMB3 in various cell types, making it ideal for studies in molecular biology and proteasome function.PSMB3 plays a crucial role in the functioning of the proteasome complex, which is responsible for degrading damaged or misfolded proteins to maintain cellular homeostasis.
Dysregulation of the proteasome complex has been implicated in various diseases, including cancer, neurodegenerative disorders, and autoimmune conditions. Therefore, studying the expression and activity of PSMB3 is essential for understanding the role of the proteasome in these pathological processes and developing targeted therapies.Overall, the PSMB3 Polyclonal Antibody (CAB9947) provides researchers with a reliable tool to investigate the function of PSMB3 in health and disease, opening new avenues for therapeutic interventions and drug discovery.
Product Name:
PSMB3 Rabbit Polyclonal Antibody
SKU:
CAB9947
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-205 of human PSMB3 (NP_002786.2).
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. The 26 S proteasome may be involved in trinucleotide repeat expansion, a phenomenon which is associated with many hereditary neurological diseases. Pseudogenes have been identified on chromosomes 2 and 12. Alternative splicing results in multiple transcript variants
Purification Method:
Affinity purification
Gene ID:
5691
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PSMB3 Rabbit pAb (CAB9947) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
