The PSMA7 Polyclonal Antibody (CAB4052) is specially designed for research involving PSMA7, a subunit of the 20S proteasome complex responsible for protein degradation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the PSMA7 protein, this antibody enables accurate detection and analysis in various cell types, making it an ideal tool for studying proteasome function in the fields of biochemistry and cell biology.
PSMA7 plays a crucial role in the degradation of misfolded or damaged proteins, as well as in the regulation of various cellular processes. Dysregulation of the proteasome complex, including PSMA7, has been linked to various diseases, including cancer, neurodegenerative disorders, and autoimmune conditions. Research on PSMA7 is instrumental in understanding the mechanisms underlying these diseases and in developing targeted therapies for their treatment.
Product Name:
PSMA7 Rabbit Polyclonal Antibody
SKU:
CAB4052
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-248 of human PSMA7 (NP_002783.1).
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9.
Purification Method:
Affinity purification
Gene ID:
5688
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PSMA7 Rabbit pAb (CAB4052) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
