The PSMA6 Polyclonal Antibody (CAB13536) is a valuable tool for researchers studying the proteasome subunit alpha type-6 (PSMA6) protein. The antibody is raised in rabbits and is highly reactive with human samples, making it suitable for a variety of research applications, including Western blot analysis. By binding specifically to the PSMA6 protein, this antibody enables the detection and analysis of PSMA6 in different cell types.PSMA6 is a key component of the proteasome complex, which plays a crucial role in degrading unwanted or damaged proteins within cells. Dysregulation of proteasome activity has been implicated in various diseases, including cancer, neurodegenerative disorders, and inflammatory conditions.
By studying PSMA6, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.Overall, the PSMA6 Polyclonal Antibody is a valuable tool for researchers interested in understanding the role of the proteasome in health and disease. Its specificity and high reactivity make it ideal for a range of research applications in fields such as oncology, neurology, and immunology.
Product Name:
PSMA6 Rabbit Polyclonal Antibody
SKU:
CAB13536
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-246 of human PSMA6 (NP_002782.1).
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome.
Purification Method:
Affinity purification
Gene ID:
5687
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PSMA6 antibody (CAB13536) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
