The PSMA5 Polyclonal Antibody (CAB5752) is a powerful tool for researchers studying the PSMA5 protein, involved in the proteasome complex responsible for protein degradation within cells. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By binding specifically to the PSMA5 protein, it enables accurate detection and analysis in a variety of cell types, making it an essential component for investigations in molecular biology and protein degradation mechanisms.
PSMA5, a subunit of the 20S proteasome, plays a crucial role in maintaining cellular homeostasis by degrading damaged or regulatory proteins. Dysregulation of the proteasome complex, including PSMA5, has been implicated in various diseases such as cancer, neurodegenerative disorders, and autoimmune conditions. By studying the function and regulation of PSMA5, researchers can gain valuable insights into disease mechanisms and potentially develop novel therapeutic strategies targeting protein degradation pathways.
Product Name:
PSMA5 Rabbit Polyclonal Antibody
SKU:
CAB5752
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-241 of human PSMA5 (NP_002781.2).
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5686
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PSMA5 Rabbit pAb (CAB5752) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
