The PSMA5 Polyclonal Antibody (CAB14053) is a specialized research tool designed for studying the proteasome subunit alpha type 5 (PSMA5), a key component of the proteasome complex involved in protein degradation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.PSMA5 is essential for maintaining cellular protein homeostasis and regulating various cellular processes, including cell cycle progression, apoptosis, and DNA repair. Dysregulation of PSMA5 has been linked to various diseases, including cancer, neurodegenerative disorders, and autoimmune conditions.
Therefore, understanding the function and regulation of PSMA5 is crucial for advancing research in these areas and developing targeted therapies.By utilizing the PSMA5 Polyclonal Antibody, researchers can effectively detect and analyze PSMA5 expression in different cell types and tissues, allowing for in-depth investigations into its role in health and disease. This antibody is a valuable tool for studies in molecular biology, biochemistry, and pharmacology, providing insights into the complex mechanisms underlying protein degradation and cellular homeostasis.
Product Name:
PSMA5 Rabbit Polyclonal Antibody
SKU:
CAB14053
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-241 of human PSMA5 (NP_002781.2).
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5686
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PSMA5 Rabbit pAb (CAB14053) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
