The PSMA3 Rabbit Monoclonal Antibody (CAB5094) is a powerful tool for researchers studying the proteasome subunit alpha type-3 (PSMA3) protein. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the PSMA3 protein, this antibody allows for precise detection and analysis in various cell types, making it an excellent choice for studies in molecular biology and cancer research.PSMA3 is a crucial component of the proteasome complex, responsible for degrading unwanted or damaged proteins within cells.
Dysfunction in the proteasome system has been linked to various diseases, including cancer, neurodegenerative disorders, and autoimmune conditions. Understanding the role of PSMA3 in protein degradation is essential for uncovering new therapeutic targets and developing treatments for these diseases. With its high specificity and reliability, the PSMA3 Rabbit Monoclonal Antibody (CAB5094) is an invaluable tool for researchers aiming to unravel the intricate mechanisms of protein degradation and its implications in disease development.
Product Name:
PSMA3 Rabbit Monoclonal Antibody
SKU:
CAB5094
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 21-150 of human PSMA3 (P25788).
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
5684
Clone Number:
ARC1234
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using PSMA3 Rabbit mAb (CAB5094) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
