The PSMA3 Polyclonal Antibody (CAB1245) is a valuable tool for researchers studying the PSMA3 protein, a subunit of the proteasome complex involved in protein degradation. This antibody is raised in rabbits and specifically targets PSMA3 in human samples, making it ideal for Western blot applications.PSMA3 plays a crucial role in maintaining cellular homeostasis by regulating protein turnover and degradation. Dysfunction in the proteasome complex, including PSMA3, has been implicated in various diseases, including cancer and neurodegenerative disorders.
Therefore, understanding the function and regulation of PSMA3 is essential for developing targeted therapies and treatments.By using the PSMA3 Polyclonal Antibody (CAB1245), researchers can detect and analyze PSMA3 expression in different cell types, allowing for a better understanding of its role in disease progression. This antibody is a valuable tool for studies in cancer research, cell biology, and protein degradation pathways.
Product Name:
PSMA3 Rabbit Polyclonal Antibody
SKU:
CAB1245
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human PSMA3 (NP_002779.1).
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
5684
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PSMA3 Rabbit pAb (CAB1245) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
