The PSMA2 Polyclonal Antibody (CAB13534) is a valuable tool for research involving PSMA2, a key component of the proteasome complex. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been extensively validated for use in Western blot applications. By specifically binding to the PSMA2 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an essential reagent for studies in molecular biology and cancer research.PSMA2, also known as proteasome subunit alpha type-2, plays a crucial role in protein degradation and turnover within cells. Dysregulation of the proteasome complex, including PSMA2, has been linked to various diseases, including cancer and neurodegenerative disorders.
Therefore, investigating the function and expression of PSMA2 is vital for understanding the underlying mechanisms of these conditions and developing targeted therapies.In conclusion, the PSMA2 Polyclonal Antibody (CAB13534) is a reliable reagent for researchers aiming to explore the role of PSMA2 in health and disease. Its high specificity and sensitivity make it an indispensable tool for unraveling the intricate pathways associated with the proteasome complex and its implications in pathology.
Product Name:
PSMA2 Rabbit Polyclonal Antibody
SKU:
CAB13534
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-234 of human PSMA2 (NP_002778.1).
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit.
Purification Method:
Affinity purification
Gene ID:
5683
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PSMA2 antibody (CAB13534) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
