The PSMA1 Polyclonal Antibody (CAB2523) is a valuable tool for researchers studying proteasome subunit alpha type-1 (PSMA1), a key component of the proteasome complex involved in protein degradation. This antibody, produced in rabbits, exhibits high specificity and reactivity towards human samples, making it suitable for use in a variety of research applications, including Western blotting.PSMA1 is essential for maintaining cellular protein homeostasis and plays a vital role in regulating processes such as cell cycle progression, DNA repair, and antigen processing. Dysregulation of the proteasome complex, including PSMA1, has been implicated in various diseases, including cancer and neurodegenerative disorders.
By targeting PSMA1 with this antibody, researchers can gain further insights into its function and potential therapeutic implications in these conditions.With its ability to specifically bind to PSMA1, this polyclonal antibody enables precise detection and analysis of the protein in different cell types, making it a valuable tool for investigations in molecular biology, biochemistry, and drug development. By understanding the role of PSMA1 in cellular processes and disease pathogenesis, researchers can advance their knowledge and potentially identify novel therapeutic targets for intervention.
Product Name:
PSMA1 Rabbit Polyclonal Antibody
SKU:
CAB2523
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-263 of human PSMA1 (NP_002777.1).
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
5682
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PSMA1 antibody (CAB2523) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
