PSMA/FOLH1 Monoclonal Antibody (CAB22212)
- SKU:
- CAB22212
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | PSMA/FOLH1 Monoclonal Antibody |
SKU: | CAB22212 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human PSMA/FOLH1 (NP_004467.1). |
Sequence: | TNIT PKHN MKAF LDEL KAEN IKKF LYNF TQIP HLAG TEQN FQLA KQIQ SQWK EFGL DSVE LAHY DVLL SYPN KTHP NYIS IINE DGNE IFNT SLFE PPPP G |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:2000 - 1:20000 |
Synonyms: | PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; PSMA/FOLH1 |
Positive Sample: | LNCaP,Mouse brain,Mouse kidney,Rat brain,Rat spleen |
Conjugate: | Unconjugated |
Cellular Localization: | cell surface, cytoplasm, extracellular exosome, plasma membrane |
Calculated MW: | 84kDa |
Observed MW: | 100kDa |
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 2346 |
Clone Number: | ARC56326 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |