The PSMA/FOLH1 Monoclonal Antibody (CAB22212) is a valuable tool for researchers studying prostate-specific membrane antigen (PSMA), also known as FOLH1. This antibody, generated in mice, is highly specific and reactive with human samples, making it ideal for use in various research applications.PSMA/FOLH1 is a transmembrane protein that is highly expressed in prostate cancer cells, making it a promising target for cancer research and therapy development. The antibody binds specifically to the PSMA/FOLH1 protein, enabling accurate detection and analysis in a variety of cell types.
Research on PSMA/FOLH1 has focused on its role in prostate cancer progression, as well as its potential as a diagnostic and therapeutic target. By understanding the function and expression of PSMA/FOLH1, researchers can gain valuable insights into the mechanisms of prostate cancer development and explore new treatment options for patients.Overall, the PSMA/FOLH1 Monoclonal Antibody (CAB22212) is a powerful tool for researchers interested in studying the biology of PSMA/FOLH1 and its implications for prostate cancer research and treatment.
Product Name:
PSMA/FOLH1 Monoclonal Antibody
SKU:
CAB22212
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human PSMA/FOLH1 (NP_004467.1).
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.
Purification Method:
Affinity purification
Gene ID:
2346
Clone Number:
ARC56326
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of LNCaP, using PSMA/FOLH1 antibody (CAB22212) at1:20000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:2000000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
