The PSD4 Polyclonal Antibody (PACO39138) is a valuable tool for researchers studying PSD4, a protein involved in various cellular processes, particularly in neuronal function and synaptic transmission. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to PSD4, this antibody enables precise detection and analysis of the protein in a variety of cell types, making it an ideal choice for studies in neuroscience and neurobiology.
PSD4, also known as a key regulator of synaptic function, plays a crucial role in the organization and function of excitatory synapses in the brain. Its involvement in synaptic plasticity and neurotransmission makes it a promising target for research on neurological disorders such as Alzheimer's disease, schizophrenia, and epilepsy. Understanding the function of PSD4 could provide insights into the mechanisms underlying these conditions and potentially lead to the development of novel therapeutic strategies.
Antibody Name:
PSD4 Antibody (PACO39138)
Antibody SKU:
PACO39138
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human PH and SEC7 domain-containing protein 4 protein (1-300AA)
Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO39138 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human breast cancer using PACO39138 at dilution of 1:100.
Background:
Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate.
Synonyms:
PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein), PSD4, EFA6B TIC
UniProt Protein Function:
PSD4: Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5- bisphosphate and phosphatidylinositol 4,5-bisphosphate. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs; GEFs, ARFChromosomal Location of Human Ortholog: 2q13Cellular Component: membrane
Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B; Exchange factor for ARF6 B; Pleckstrin homology and SEC7 domain-containing protein 4; Telomeric of interleukin-1 cluster protein
