The PSCA Polyclonal Antibody (CAB5614) is a valuable tool for researchers studying Prostate Stem Cell Antigen (PSCA), a protein implicated in prostate cancer development and progression. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various applications such as Western blot and immunohistochemistry.PSCA is known to play a crucial role in promoting prostate cancer growth and metastasis, making it a promising target for therapeutic intervention. The PSCA Polyclonal Antibody specifically recognizes the PSCA protein, enabling researchers to detect and analyze its expression in cancer cells and tumor tissues.
This antibody is ideal for investigations in oncology and molecular biology, aiding in the understanding of PSCA function and its potential as a biomarker or therapeutic target in prostate cancer research.Overall, the PSCA Polyclonal Antibody (CAB5614) provides researchers with a reliable tool for studying the role of PSCA in prostate cancer biology and may contribute to the development of novel strategies for diagnosing and treating this commonly diagnosed cancer.
Product Name:
PSCA Rabbit Polyclonal Antibody
SKU:
CAB5614
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 12-114 of human PSCA (NP_005663.2).
This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
8000
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using PSCA Rabbit pAb (CAB5614) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
