The PSAT1 Polyclonal Antibody (PAC040318) is a valuable tool for researchers studying PSAT1, an enzyme involved in the biosynthesis of serine. This antibody, produced in rabbits, has high reactivity with human samples and is validated for use in Western blot applications. By binding to the PSAT1 protein, it enables the detection and analysis of this enzyme in various cell types.PSAT1 plays a crucial role in serine metabolism, which is essential for cell proliferation and growth. Dysregulation of PSAT1 has been linked to various diseases, including cancer and neurological disorders.
By studying the function of PSAT1, researchers can gain insights into the pathways impacted by serine metabolism and potentially identify target areas for therapeutic intervention.This antibody is an excellent choice for studies in the fields of metabolism, cancer biology, and neurology, where understanding the role of PSAT1 is key to advancing our knowledge of disease mechanisms and developing new treatment strategies.
Antibody Name:
Psat1 Antibody (PACO40318)
Antibody SKU:
PACO40318
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Mouse
Immunogen:
Recombinant Mouse Phosphoserine aminotransferase protein (1-370AA)
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
PSAT1: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. Defects in PSAT1 are the cause of phosphoserine aminotransferase deficiency (PSATD). PSATD is characterized biochemically by low plasma and cerebrospinal fluid concentrations of serine and glycine and clinically by intractable seizures, acquired microcephaly, hypertonia, and psychomotor retardation. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Amino Acid Metabolism - glycine, serine and threonine; Cofactor and Vitamin Metabolism - vitamin B6; EC 2.6.1.52; TransferaseChromosomal Location of Human Ortholog: 19 A|19 10.86 cMCellular Component: cytoplasm; cytosolMolecular Function: phosphoserine transaminase activityBiological Process: L-serine biosynthetic process
