The PSA Polyclonal Antibody (CAB11636) is a valuable tool for research involving PSA (Prostate Specific Antigen), a protein produced by the prostate gland and commonly used as a biomarker for prostate cancer. This polyclonal antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blot and immunohistochemistry.PSA is a key marker in the diagnosis and monitoring of prostate cancer, as elevated levels of PSA in the blood may indicate the presence of the disease. This antibody is specifically designed to target and detect PSA in tissue samples, enabling researchers to study its expression and distribution in prostate cancer cells.
Its use in immunohistochemistry provides valuable insights into the localization of PSA in tumor tissues, aiding in the understanding of disease progression and prognosis.Furthermore, the PSA Polyclonal Antibody is a reliable tool for studying the role of PSA in other physiological and pathological processes, such as benign prostatic hyperplasia and male infertility. Its high specificity and sensitivity make it an essential reagent for researchers investigating the biology of PSA and its implications in various clinical conditions.
Product Name:
PSAP Polyclonal Antibody
SKU:
CAB21761
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 275-524 of human PSAP (NP_002769.1).
This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Purification Method:
Affinity purification
Gene ID:
5660
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using [KO Validated] PSAP Rabbit pAb (CAB21761) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
