The PRUNE2 Antibody (PAC044244) is a valuable tool for researchers studying the PRUNE2 protein's role in cellular processes and diseases. This polyclonal antibody, produced in rabbits, is highly specific to human samples and is suitable for Western blot applications. By binding to the PRUNE2 protein, this antibody enables accurate detection and analysis in various cell types, making it an essential component for studies in cancer research and beyond.PRUNE2, also known as prune homolog 2, is involved in various cellular functions, including cell proliferation, migration, and survival.
Dysregulation of PRUNE2 has been implicated in diseases such as cancer, neurodevelopmental disorders, and metabolic diseases. Understanding the function of PRUNE2 is crucial for uncovering its role in these conditions and potentially identifying new therapeutic targets.Researchers can trust the PRUNE2 Antibody (PAC044244) to provide reliable and reproducible results in their experiments, ultimately advancing our understanding of PRUNE2's significance in health and disease.
Antibody Name:
PRUNE2 Antibody (PACO44244)
Antibody SKU:
PACO44244
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Protein prune homolog 2 protein (1-250AA)
Form:
Liquid
Storage Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method:
Antigen Affinity Purified
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO44244 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human brain tissue using PACO44244 at dilution of 1:100.
Background:
May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells.
Synonyms:
Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1), PRUNE2, BMCC1 BNIPXL C9orf65 KIAA0367
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, whose members play roles in many cellular processes including apotosis, cell transformation, and synaptic function. Several functions for this protein have been demonstrated including suppression of Ras homolog family member A activity, which results in reduced stress fiber formation and suppression of oncogenic cellular transformation. A high molecular weight isoform of this protein has also been shown to colocalize with Adaptor protein complex 2, beta-Adaptin and endodermal markers, suggesting an involvement in post-endocytic trafficking. In prostate cancer cells, this gene acts as a tumor suppressor and its expression is regulated by prostate cancer antigen 3, a non-protein coding gene on the opposite DNA strand in an intron of this gene. Prostate cancer antigen 3 regulates levels of this gene through formation of a double-stranded RNA that undergoes adenosine deaminase actin on RNA-dependent adenosine-to-inosine RNA editing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
