The PRUNE2 Polyclonal Antibody (PAC011513) is a valuable tool for research involving the PRUNE2 protein, known for its role in various cellular processes such as cell proliferation and migration. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in applications like Western blotting.PRUNE2, also known as prune homolog 2, is involved in regulating cell growth and survival, making it a key player in cancer research and other disease studies. By targeting the PRUNE2 protein, researchers can gain insights into its functions and potential therapeutic applications in conditions such as cancer and neurodevelopmental disorders.
The PRUNE2 Polyclonal Antibody is an essential tool for scientists looking to study the molecular mechanisms of PRUNE2 and its impact on cellular processes. Its high reactivity and specificity make it a reliable choice for experiments in fields such as oncology and neurobiology. Unlock the potential of PRUNE2 research with this highly effective antibody.
The protein encoded by this gene belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, whose members play roles in many cellular processes including apotosis, cell transformation, and synaptic function. Several functions for this protein have been demonstrated including suppression of Ras homolog family member A activity, which results in reduced stress fiber formation and suppression of oncogenic cellular transformation. A high molecular weight isoform of this protein has also been shown to colocalize with Adaptor protein complex 2, beta-Adaptin and endodermal markers, suggesting an involvement in post-endocytic trafficking. In prostate cancer cells, this gene acts as a tumor suppressor and its expression is regulated by prostate cancer antigen 3, a non-protein coding gene on the opposite DNA strand in an intron of this gene. Prostate cancer antigen 3 regulates levels of this gene through formation of a double-stranded RNA that undergoes adenosine deaminase actin on RNA-dependent adenosine-to-inosine RNA editing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
