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PRSS2 Rabbit Monoclonal Antibody (CAB19275)

SKU:
CAB19275
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
PRSS2
TRY2
TRY8
TRYP2
trypsin-2
Research Area:
Cell Biology
$167 - $503
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:PRSS2 Rabbit Monoclonal Antibody
SKU:CAB19275
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PRSS2 (P07478).
Sequence:MNLL LILT FVAA AVAA PFDD DDKI VGGY ICEE NSVP YQVS LNSG YHFC GGSL ISEQ WVVS AGHC YKSR IQVR LGEH NIEV LEGN EQFI NAAK IIRH PKYN
Tested Applications:WB IHC-P ELISA
Recommended Dilution:WB,1:2000 - 1:6000 IHC-P,1:50 - 1:200
Synonyms:TRY2; TRY8; TRYP2; PRSS2
Positive Sample:Mouse pancreas,Rat pancreas
Conjugate:Unconjugated
Cellular Localization:Secreted, extracellular space.
Calculated MW:26kDa
Observed MW:30kDa

This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:5645
Clone Number:ARC2453
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using PRSS2 Rabbit mAb (CAB19275) at 1:5000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.

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