The PRSS12 Polyclonal Antibody (CAB14319) is a valuable tool for researchers studying PRSS12, a protease enzyme associated with various biological processes, including protein degradation and tissue remodeling. This antibody, raised in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By targeting the PRSS12 protein, this antibody enables accurate detection and analysis in a range of cell types, making it ideal for investigations in areas such as cell biology and neuroscience.PRSS12, also known as neurosin, is known to play a critical role in neurodegenerative diseases, including Alzheimer's and Parkinson's.
Its involvement in protein processing and degradation makes it a promising target for research aimed at understanding the pathophysiology of these conditions. Studies on PRSS12 are essential for developing potential therapeutic strategies that target the enzyme's activity and its impact on disease progression.Overall, the PRSS12 Polyclonal Antibody offers researchers a reliable tool for investigating the role of PRSS12 in various biological processes and diseases, providing valuable insights for the development of novel treatment approaches.
Product Name:
PRSS12 Rabbit Polyclonal Antibody
SKU:
CAB14319
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 21-300 of human PRSS12 (NP_003610.2).
This gene encodes a member of the trypsin family of serine proteases and contains a signal peptide, a proline-rich region, a Kringle domain, four scavenger receptor cysteine-rich domains, and a trypsin-like serine protease domain. The protein, sometimes referred to as neurotrypsin or motopsin, is secreted from neuronal cells and localizes to the synaptic cleft. Studies in mice show that this protein cleaves a protein, agrin, that is important for the formation and maintenance of exitatory synapses. Defects in this gene cause a form of autosomal recessive cognitive impairment (MRT1).
Purification Method:
Affinity purification
Gene ID:
8492
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PRSS12 Rabbit pAb (CAB14319) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
