Prss1 Antibody (PACO29208)
- SKU:
- PACO29208
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Prss1 Antibody (PACO29208)
The PRSS1 Polyclonal Antibody (PAC02908) is a valuable tool for researchers studying PRSS1, a serine protease enzyme involved in digestive processes. This antibody, produced in rabbits, is highly specific to human PRSS1 and has been validated for use in Western blot applications. By binding to the PRSS1 protein, this antibody allows for the detection and analysis of PRSS1 in various cell types, making it an excellent choice for studies in gastrointestinal biology and pancreatic disorders.PRSS1 is known for its role in the digestion of proteins in the small intestine, and mutations in the PRSS1 gene have been linked to pancreatitis, a painful and potentially life-threatening condition.
The ability to accurately detect and study PRSS1 is crucial for understanding its function in normal digestion and its impact on pancreatic health. Research into PRSS1 holds promise for the development of new treatments for pancreatitis and other digestive disorders, making this antibody an essential tool for scientists in the field.
| Antibody Name: | Prss1 Antibody (PACO29208) |
| Antibody SKU: | PACO29208 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Rat |
| Immunogen: | Recombinant Rat Anionic trypsin-1 protein (24-246AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | extracellular space, serine-type endopeptidase activity, digestion, proteolysis, response to caffeine, response to nicotine, response to nutrient, response to organic substance |
| Synonyms: | Anionic trypsin-1 (EC 3.4.21.4) (Anionic trypsin I) (Pretrypsinogen I) (Serine protease 1), Prss1, Try1 |
| UniProt Protein Function: | trypsin 1: Has activity against the synthetic substrates Boc-Phe- Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val- Pro-Arg-Mec. The single-chain form is more active than the two- chain form against all of these substrates. Defects in PRSS1 are a cause of pancreatitis (PCTT). A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks. Belongs to the peptidase S1 family. |
| UniProt Protein Details: | Protein type:EC 3.4.21.4; Protease; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 4q23 Cellular Component: extracellular region; extracellular space Molecular Function:calcium ion binding; serine-type endopeptidase activity Biological Process: collagen catabolic process; digestion; proteolysis; response to caffeine; response to nicotine; response to nutrient; response to organic substance |
| NCBI Summary: | catalyzes the cleavage of Arg-Xaa, Lys-Xaa [RGD, Feb 2006] |
| UniProt Code: | P00762 |
| NCBI GenInfo Identifier: | 6981420 |
| NCBI Gene ID: | 24691 |
| NCBI Accession: | NP_036767.1 |
| UniProt Related Accession: | P00762 |
| Molecular Weight: | 39.59kD |
| NCBI Full Name: | anionic trypsin-1 |
| NCBI Synonym Full Names: | protease, serine 1 |
| NCBI Official Symbol: | Prss1Â Â |
| NCBI Official Synonym Symbols: | Try1; PTRYI; RATPTRYIÂ Â |
| NCBI Protein Information: | anionic trypsin-1 |
| UniProt Protein Name: | Anionic trypsin-1 |
| UniProt Synonym Protein Names: | Anionic trypsin I; Pretrypsinogen I; Serine protease 1 |
| Protein Family: | Anionic trypsin |
| UniProt Gene Name: | Prss1Â Â |
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