The PRRt2 Polyclonal Antibody (CAB16027) is a valuable tool for researchers studying the PRRT2 protein, which is associated with paroxysmal kinesigenic dyskinesia (PKD) and other neurological disorders. This antibody, generated from rabbits, exhibits high specificity and sensitivity when used in assays such as Western blotting. By binding to the PRRT2 protein, researchers can detect and analyze its expression in various cell types, providing important insights into the molecular mechanisms underlying PKD and related conditions.PRRT2 is a synaptic protein that plays a crucial role in regulating neuronal excitability and neurotransmitter release.
Mutations in the PRRT2 gene have been linked to PKD, a rare neurological disorder characterized by sudden, involuntary movements triggered by movement. Understanding the function of PRRT2 is essential for unraveling the pathophysiology of PKD and developing targeted therapies for affected individuals.The PRRt2 Polyclonal Antibody (CAB16027) is a reliable reagent for investigating the role of PRRT2 in neurological disorders, making it an essential tool for researchers in the field of neuroscience and genetics. Its specificity and sensitivity ensure accurate results, allowing for further advancements in the study of PKD and related conditions.
Product Name:
PRRT2 Rabbit Polyclonal Antibody
SKU:
CAB16027
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-130 of human PRRT2 (NP_660282.2).
This gene encodes a transmembrane protein containing a proline-rich domain in its N-terminal half. Studies in mice suggest that it is predominantly expressed in brain and spinal cord in embryonic and postnatal stages. Mutations in this gene are associated with episodic kinesigenic dyskinesia-1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
112476
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PRRT2 Rabbit pAb (CAB16027) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
