The PRR5 Polyclonal Antibody (CAB15170) is a valuable tool for researchers studying the PRR5 protein, a key player in innate immunity and inflammatory responses. This antibody, derived from rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the PRR5 protein, this antibody enables accurate detection and analysis in various cell types, making it an ideal choice for studies in immunology and infectious diseases research.
PRR5, also known as a pattern recognition receptor, plays a crucial role in recognizing and responding to various pathogens, including bacteria and viruses. Its involvement in innate immune responses makes it a promising target for investigations into infectious diseases, autoimmune disorders, and inflammation. Understanding the function of PRR5 is essential for developing new therapeutic strategies that target the immune system's natural defense mechanisms.
Product Name:
PRR5 Rabbit Polyclonal Antibody
SKU:
CAB15170
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 190-388 of human PRR5 (NP_851850.1).
This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.
Purification Method:
Affinity purification
Gene ID:
55615
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PRR5 Rabbit pAb (CAB15170) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
