PRR5 Rabbit Polyclonal Antibody (CAB15170)
- SKU:
- CAB15170
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
Product Name: | PRR5 Rabbit Polyclonal Antibody |
SKU: | CAB15170 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 190-388 of human PRR5 (NP_851850.1). |
Sequence: | SRGV TEDY LRLE TLVQ KVVS PYLG TYGL HSSE GPFT HSCI LEKR LLRR SRSG DVLA KNPV VRSK SYNT PLLN PVQE HEAE GAAA GGTS IRRH SVSE MTSC PEPQ GFSD PPGQ GPTG TFRS SPAP HSGP CPSR LYPT TQPP EQGL DPTR SSLP RSSP ENLV DQIL ESVD SDSE GIFI DFGR GRGS GMSD LEGS GGRQ SVV |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | PP610; PROTOR1; PROTOR-1; FLJ20185k; PRR5 |
Positive Sample: | 293T,HepG2,SH-SY5Y,Mouse liver,Mouse brain,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol |
Calculated MW: | 43kDa |
Observed MW: | 45kDa |
This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.
Purification Method: | Affinity purification |
Gene ID: | 55615 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |